Literature summary for 2.1.1.364 extracted from

Guitot, K.; Scarabelli, S.; Drujon, T.; Bolbach, G.; Amoura, M.; Burlina, F.; Jeltsch, A.; Sagan, S.; Guianvarch, D.
Label-free measurement of histone lysine methyltransferases activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (2014), Anal. Biochem., 456, 25-31.

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Application

Application	Comment	Organism
analysis	development of a simple reliable label-free MALDI-TOF MS-based assay for the detection and quantification of peptide methylation, using SET7/9 as a model enzyme. The use of expensive internal standard often required in mass spectrometry quantitative analysis is not necessary in this assay	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sinefungin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8WTS6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ARTKQTARKSTGGKAPRK(biot)G + S-adenosyl-L-methionine	-	Homo sapiens	ART-methyl-KQTARKSTGGKAPRK(biot)G + S-adenosyl-L-homocysteine	-	?

Synonyms

Synonyms	Comment	Organism
SET7/9	-	Homo sapiens
SetD7	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.02	-	pH 9.8, 37°C	Homo sapiens	sinefungin

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Release 2023.1 (January 2023)